CYP1A2 polymorphisms are associated with lung cancer and bladder cancer risk in Caucasians. Studies have shown that a genetic polymorphism in the CYP1A2 gene can affect the rate at which caffeine is metabolized in the liver. However, it is important to note that caffeine can cross the placental barrier, and therefore, can affect the fetus. However, rs762551(A) ... [PMID 22648710] CYP1A2 and coffee intake and the modifying effect of sex, age, and … This has a direct consequence on blood pressure, as well as fluid retention in the body. The consequence of being a “rapid” or a “slow” metabolizer of caffeine can have effects on an individual’s cardiovascular health. After all, it would be good to know if you are prone to guzzling down a little too much, especially when your caffeine sensitivity scale is tipped at the wrong end. This website uses cookies to ensure you get the best experience on our website. This occurs typically 12-24 hours after stopping caffeine. A study aimed to tie these concepts together to find the relationship between this gene and blood pressure (BP). Such people have two copies of the fast variant. Reduced calcium levels in the body can lead to osteoporosis. rs2472297 is a SNP located between the CYP1A1 and CYP1A2 genes on ch 15q24.. A meta-analysis of four GWAS studies of coffee consumption among a total of ~8,000 coffee drinkers of European ancestry found that the rs2472297(T) was strongly associated with increased consumption (p = 5.4 x 10e-14). A study conducted on 553 individuals found that people with this genotype had a 70% reduction in the risk of a heart attack on increased consumption of caffeine. One of these is a key enzyme called CYP1A2, which is responsible for inactivating 95% of all ingested caffeine. The CYP1A2 gene regulates the synthesis of the enzyme, and small variations in this gene are associated with the efficiency of caffeine metabolism. Resting metabolic rate describes the rate at which you burn calories at rest. Coffee is a major source of caffeine, which is metabolized by the polymorphic cytochrome P450 1A2 (CYP1A2) enzyme. Exons 2–6 are highly conserved among the human, mouse, and rat. This was also observed in a study conducted on 415 Japanese women. Over 95% of caffeine is metabolized by the CYP1A2 enzyme, which is encoded by the CYP1A2gene, and is involved in the demethylation of caffeine into the primary metabolites paraxanthine, theophylline, and theobromine (21). CYP1A2 Gene Detail. The gene codes for the CYP1A2 enzyme, which plays a role in both coffee and oestrogen metabolism. Analyze your CYP1A2 gene variants for Caffeine Metabolism, Find out if you carry the Slow or the Rapid variant of CYP1A2 gene, https://jamanetwork.com/journals/jama/fullarticle/202502, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474926/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1735605/, https://www.researchgate.net/publication/223974368_Caffeine_intake_and_CYP1A2_variants_associated_with_high_caffeine_intake_protect_non-smokers_from_hypertension, https://www.nature.com/articles/pr201770#:~:text=Maternal%20caffeine%20intake%20may%20increase,8%2C%209%2C%2010), Morning Person or a Night Owl: How Genes Influence Your Circadian Rhythm, How Genes Influence Caffeine-induced Insomnia, How Genes Influence The Risk Of Obstructive Sleep Apnea, How Genes Influence Excessive Daytime Sleepiness. The positive effects of coffee include lowering a feeling of tiredness and increasing alertness; however, it can also narrow the blood vessels. Variations in this gene broadly divide people into two groups of metabolizers: In particular, two Single Nucleotide Polymorphisms (SNP) are found to influence caffeine metabolism: The haplotype CYP1A2*1F is associated with this variation. The large variability of CYP1A2 activity influences the clearance of caffeine and may be affected by factors such as gender, race, genetic polymorphisms, disease, and exposure to inducers 16,17,19. Cortisol is a stress-related hormone and plays a role in protecting the body from stress, as well as reducing inflammation. Caffeine offers a range of benefits from something as small as over an afternoon slump to reducing the risk of some serious health conditions like heart diseases. ... Carriers of the CYP1A2 AA genotype may exhibit an increased total daily coffee intake, … This protein is involved in the breakdown of stimulants, drugs, nutrients, and other xenobiotics. The babies are also at risk of being too small during the time of pregnancy. Caffeine is metabolized by an enzyme in the liver that is encoded for by the CYP1A2 gene. In the same study, CYP1A2 activity had a negative association with blood pressure among ex-smokers. Fast metabolizers of caffeine may have a high caffeine tolerance. remains controversial. It also plays a role in phase-1 detoxification, particularly in how well your body deals with HCAs and PAHs found in charred meats. What is CYP1A2, aka the caffeine gene? In the body, CYP1A2 accounts for around 95% of caffeine metabolism. If you're primarily interested in coffee for the sake of fat loss, it may be wise not to consume it excessively and end up making your body more tolerant of caffeine. Many studies, as noted above, seem to link the activity of this gene to caffeine intake. Initially, the increase in metabolism upon caffeine consumption can be evident. In a study conducted on 2014 people, people who were slow metabolizers of caffeine (C variant) and who consumed more than 3 cups of coffee per day had an association with increased risk for myocardial infarction. It is a common ingredient in medications that are meant to treat drowsiness, migraines, and headaches. This, in turn, increases your blood pressure for some time. Rapid metabolizers of coffee have the AA genotype and may unravel the protective effects of caffeine in the system. To … In humans, the CYP1A2 enzyme is encoded by the CYP1A2 gene. Gene in Focus: Part 4 - CYP1A2 (Caffeine) The next gene we'll be looking at is CYP1A2. Polymorphisms within the CYP1A2 gene were recently shown to be associated with coffee intake (4 – 6). When consumed in excess quantities, caffeine can lead to irregular heartbeat and breathing. Caffeine does not accumulate in our body, but is broken down in the liver. Identification of this tendency will help in moderating coffee consumption, taking into account the individual's caffeine metabolism status. The enzyme responsible for metabolism of caffeine is coded for by the gene CYP1A2. A previous study showed that C->A polymorphism in the intron I of CYP1A2 was associated with increased caffeine metabolism. ... approximately two cups of … Early research also suggests that caffeine supports fat-burning during exercise. Abstract. Anything exceeding that can be harmful to the body. ... Coffee intake, glucose … Coffee And CYP1A2: 3 Ways High Caffeine Intake Can Affect You! The CYP1A2 gene regulates the synthesis of the enzyme, and small variations in this gene are associated with the efficiency of caffeine metabolism. The gene also plays a role in regulating an infant’s weight during the pregnancy of a woman,  and this has a link with caffeine intake. The primary purpose of it is to act as a toxin to defend the plants against herbivores. 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