Ciproxin 500: un antibiotico per la cura di molte infezioni. La ciprofloxacina agisce uccidendo i batteri che provocano le infezioni. As a precautionary measure, it is preferable to avoid the use of ciprofloxacin during pregnancy. Microrganismi sensibili al Ciproxin® Ciproxin® è efficace contro batteri gram positivi e gram negativi. ECG monitoring should be undertaken, because of the possibility of QT interval prolongation. For epididymo-orchitis and pelvic inflammatory diseases, empirical ciprofloxacin should only be considered in combination with another appropriate antibacterial agent (e.g. Patients taking ciprofloxacin should be advised to avoid direct exposure to either extensive sunlight or UV irradiation during treatment (see section 4.8). Therefore, caution should be taken when using fluoroquinolones, including ciprofloxacin, in these populations. Funziona solo con particolari ceppi di batteri. Class IA and III anti-arrhythmics, tricyclic antidepressants, macrolides, antipsychotics) (see section 4.4). Co-administration of ciprofloxacin may increase blood levels of zolpidem, concurrent use is not recommended. Variabile anche a seconda dell’età, della sede dell’infezione, della gravità del paziente e del peso corporeo nel caso dei bambini. ADRs derived from clinical studies and post-marketing surveillance with Ciproxin (oral, intravenous, and sequential therapy) sorted by categories of frequency are listed below. a cephalosporin) unless ciprofloxacin-resistant Neisseria gonorrhoeae can be excluded. Consideration should be given to official guidance on the appropriate use of antibacterial agents. painful swelling, inflammation), the treatment with Ciprofloxacin should be discontinued and alternative treatment should be considered. Corticosteroids should not be used if signs of tendinopathy occur. Ciproxin® anvendes til behandling af alvorlige betændelser (infektioner), fremkaldt af bakterier. Ciproxin® indeholdt det virksomme stof ciprofloksacin og blev taget af markedet pga. Non-clinical data reveal no special hazards for humans based on conventional studies of single dose toxicity, repeated dose toxicity, carcinogenic potential, or toxicity to reproduction. Clinical surveillance and appropriate adjustment of clozapine dosage during and shortly after co-administration with ciprofloxacin are advised (see section 4.4). If in doubt, talk to your doctor. • Lower respiratory tract infections due to Gram-negative bacteria. Stellen Sie daher sicher, dass Sie wissen, wie Sie auf Ciproxin 500 mg Filmtabletten reagieren, ehe Sie sich an das Steuer eines Fahrzeugs setzen oder Maschinen bedienen. per infusione flacone 100 ml; ciproxin 250 mg 10 compresse (scheda corrente) ciproxin 250 mg/5 ml granuli e solv. per sosp. Posologia Ciproxin 500 mg. Generalmente però la posologia Ciproxin 500 mg fa riferimento in modo specifico ad una cistite acuta non complicata, per via orale vengono assimilate pillole Ciproxin 500 mg una al giorno per due giorni. Che cosa è ciproxin 6cpr riv 500mg? Ciproxin 500 mg Filmtabletten können Ihre Aufmerksamkeit beeinträchtigen. Consequently, caution is advised when treating patients with these infections. Studies with mature animals (rat, dog) revealed no evidence of cartilage lesions. Inhalation anthrax post-exposure prophylaxis and curative treatment for persons able to receive treatment by oral route when clinically appropriate. Treatment of some infections (e.g. 4-5 hours and the bioavailability of the oral suspension ranges from 50 to 80%. 10 mg/kg body weight twice daily to 15 mg/kg body weight twice daily with a maximum of 500 mg per dose. Per quanto riguarda le specifiche inerenti alle dosi e alla modalità d’assunzione, queste ti verranno date direttamente dalla persona che ti sta seguendo in questo percorso. Voksne: Sædvanligvis tages 250-500 mg 2 gange i døgnet. Indice stock/ Dosing in children with impaired renal and/or hepatic function has not been studied. All in-vitro mechanisms of resistance are commonly observed in clinical isolates. An overdose of 12 g has been reported to lead to mild symptoms of toxicity. Breakpoints separate susceptible strains from strains with intermediate susceptibility and the latter from resistant strains: 1 Staphylococcus spp. Ligeledes i sjældne tilfælde forekommer symptomer fra nervesystemet: svimmelhed, rysten pÃ¥ hænderne, hovedpine, mareridt og konfusion. I.v.-infusie: 10–15 mg/kg lichaamsgewicht 2×/dag en maximaal 400 mg Ansvarsfraskrivelse: Alle informationer om medicin pÃ¥ stilles til gratis rÃ¥dighed for vores brugere, men erstatter ikke lægekonsultation eller vejledning fra behandlere, apoteker o.lign. This effect was comparable to that of other gyrase inhibitors. Treatment of infections due to certain bacteria (e.g. Cases of aortic aneurysm and dissection, sometimes complicated by rupture (including fatal ones), and of regurgitation/incompetence of any of the heart valves have been reported in patients receiving fluoroquinolones (see section 4.8). Indholdet mÃ¥ under ingen omstændigheder anvendes til at stille diagnoser eller igangsætte behandling. 10–20 beats per minute. Severely impaired renal function leads to increased half lives of ciprofloxacin of up to 12 h. Non-renal clearance of ciprofloxacin is mainly due to active trans-intestinal secretion and metabolism. Dietary calcium as part of a meal does not significantly affect absorption. Although lidocaine treatment was well tolerated, a possible interaction with ciprofloxacin associated with side effects may occur upon concomitant administration. Trattamento curativo: lo stesso per … Although no clinical data are available on a possible interaction with ciprofloxacin, similar effects can be expected upon concomitant administration (see section 4.4). Complicated urinary tract infections and pyelonephritis. milk, yoghurt, calcium-fortified orange juice) with ciprofloxacin should be avoided because absorption of ciprofloxacin may be reduced. The risk of tendinitis and tendon rupture is increased in older patients, patients with renal impairment, patients with solid organ transplants, and those treated concurrently with corticosteroids. The recommended use in human subjects is based primarily on in-vitro susceptibility and on animal experimental data together with limited human data. The frequency analysis takes into account data from both oral and intravenous administration of ciprofloxacin. OBS: Dette præparat er udgÃ¥et og informationerne opdateres ikke længere. ** Cases of aortic aneurysm and dissection, sometimes complicated by rupture (including fatal ones), and of regurgitation/incompetence of any of the heart valves have been reported in patients receiving fluoroquinolones (see section 4.4). In clinical studies, it was demonstrated that concomitant use of duloxetine with strong inhibitors of the CYP450 1A2 isozyme such as fluvoxamine, may result in an increase of AUC and Cmax of duloxetine. Hvis du er i tvivl om, hvordan et lægemiddel skal anvendes, bør du altid konsultere din praktiserende læge eller spørge pÃ¥ apoteket. To bookmark a medicine you must sign up and log in. Reporting suspected adverse reactions after authorisation of the medicinal product is important. other than Shigella dysenteriae type 1 and empirical treatment of severe travellers' diarrhoea, Diarrhoea caused by Shigella dysenteriae type 1, Intra-abdominal infections due to Gram-negative bacteria, Infections of the skin and soft tissue caused by Gram-negative bacteria. Indice. Pseudomonas aeruginosa, Acinetobacter or Staphylococci) may require higher ciprofloxacin doses and co-administration with other appropriate antibacterial agents. Per l’elenco completo degli eccipienti, vedere paragrafo 6.1. The serum elimination half-life in subjects with normal renal function is approximately 4-7 hours. sevelamer or lanthanum carbonate), sucralfate or antacids, and highly buffered drugs (e.g. midlets bivirkninger, risiko for udvikling af multiresistente bakterier mv. vascular disorders such as Takayasu arteritis or giant cell arteritis, or known atherosclerosis, or Sjögren's syndrome) or additionally. The INR should be monitored frequently during and shortly after co-administration of ciprofloxacin with a vitamin K antagonist (e.g., warfarin, acenocoumarol, phenprocoumon, or fluindione). This site uses cookies. If taken on an empty stomach, the active substance is absorbed more rapidly. De behandeling zo spoedig mogelijk beginnen en de behandelduur is 60 dagen vanaf de bevestiging van de blootstelling aan Bacillus anthracis. If clinical improvement is not achieved after 3 days of treatment, the therapy should be reconsidered. Inhalation anthrax post-exposure prophylaxis and curative treatment for persons able to receive treatment by oral route when clinically appropriate. Symptoms in overdose consist of dizziness, tremor, headache, tiredness, seizures, hallucinations, confusion, abdominal discomfort, renal and hepatic impairment as well as crystalluria and haematuria. As a fluoroquinolone antibacterial agent, the bactericidal action of ciprofloxacin results from the inhibition of both type II topoisomerase (DNA-gyrase) and topoisomerase IV, required for bacterial DNA replication, transcription, repair and recombination. An acute overdose of 16 g has been reported to cause acute renal failure. glibenclamide) or with insulin. Gonococcal uretritis, cervicitis, epididymo-orchitis and pelvic inflammatory diseases may be caused by fluoroquinolone-resistant Neisseria gonorrhoeae isolates. A 500 mg oral dose given every 12 hours has been shown to produce an area under the serum concentration-time curve (AUC) equivalent to that produced by an intravenous infusion of 400 mg ciprofloxacin given over 60 minutes every 12 hours. Assunzione di ciproxin 500 mg per 6 giorni una al giorno e problemi ai tendini. immobilisation). Complicated urinary tract infections and acute pyelonephritis. The degree of cross-resistance between ciprofloxacin and other fluoroquinolones that results is variable. Per quel che riguarda le infezioni delle vie urinaie complicate la posologia Ciproxin 500 mg riguarda due somministrazioni per 1-2 settimane. Class IA and III anti-arrhythmics, tricyclic antidepressants, macrolides, antipsychotics), • uncorrected electrolyte imbalance (e.g. Effects of other products on ciprofloxacin: Ciprofloxacin, like other fluoroquinolones, should be used with caution in patients receiving drugs known to prolong QT interval (e.g. 400 South Oak Way, Reading, Berkshire, RG2 6AD. In children, arthropathy is reported to occur commonly (see section 4.4). Ciproxin® øger virkningen af astmamidlet teofyllin (se Astma), (se i øvrigt evt. The AUC values were 17.4 mg*h/L (range 11.8-32.0 mg*h/L) and 16.5 mg*h/L (range 11.0-23.8 mg*h/L) in the respective age groups. milk, yoghurt) or mineral-fortified fruit-juice (e.g. Senebetændelse især i hælsenen (akillessenen) er beskrevet. of theophylline) may be necessary (see section 4.5). • Concomitant administration of ciprofloxacin and tizanidine (see section 4.5). Ciproxin - Compressa è un farmaco a base del principio attivo Ciprofloxacina, appartenente alla categoria degli Antibatterici chinolonici e nello specifico Fluorochinoloni.E' commercializzato in Italia dall'azienda Bayer S.p.A.. Ciproxin - Compressa può essere prescritto con Ricetta RR - medicinali soggetti a prescrizione medica. - Uncomplicated acute cystitis. Therefore, patients taking these substances concomitantly with ciprofloxacin should be monitored closely for clinical signs of overdose, and determination of serum concentrations (e.g. The metabolites display in-vitro antimicrobial activity but to a lower degree than the parent compound. Ciprofloxacin should be used with caution in patients with CNS disorders which may be predisposed to seizure. Nevertheless, in very rare instances, after microbiological documentation of the causative organism and evaluation of the risk/benefit balance, ciprofloxacin may be prescribed to these patients for the treatment of certain severe infections, particularly in the event of failure of the standard therapy or bacterial resistance, where the microbiological data may justify the use of ciprofloxacin. The in-vitro activity of ciprofloxacin against Mycobacterium tuberculosis might give false negative bacteriological test results in specimens from patients currently taking ciprofloxacin. Ciproxin 500 mg compresse rivestite con film è indicato nel trattamento delle infezioni riportate sotto (vedere paragrafi 4.4 e 5.1). Ciproxin 500 mg compresse a rilascio modificato . Glucose-6-phosphate dehydrogenase deficiency. The use of ciprofloxacin for specific severe infections other than those mentioned above has not been evaluated in clinical trials and the clinical experience is limited. In juvenile and prenatal animals exposed to quinolones, effects on immature cartilage have been observed, thus, it cannot be excluded that the drug could cause damage to articular cartilage in the human immature organism / foetus (see section 5.3). Ciprofloxacin is largely excreted unchanged both renally and, to a smaller extent, faecally. IVOMEC 1 gc ditro la nuca con graffietto subito e dopo 8 gg oppure 1gc diluta in 10 gc di glicole etilenico direttamente nel becco per 5 gg. Cases of hepatic necrosis and life-threatening hepatic failure have been reported with ciprofloxacin (see section 4.8). Yleisiä ohjeita. Co-administration of probenecid and ciprofloxacin increases ciprofloxacin serum concentrations. In uncomplicated acute cystitis Ciprofloxacin should be used only when it is considered inappropriate to use other antibacterial agents that are commonly recommended for the treatment of these infections. If vision becomes impaired or any effects on the eyes are experienced, an eye specialist should be consulted immediately. Dosis skal nedsættes ved dÃ¥rligt fungerende nyrer. Broncho-pulmonary infections in cystic fibrosis. Ciprofloxacin may also be used to treat severe infections in children and adolescents when this is considered to be necessary. Ciprofloxacin treatment should be initiated only by physicians who are experienced in the treatment of cystic fibrosis and/or severe infections in children and adolescents. To view the changes to a medicine you must sign up and log in. Ciprofloxacin is present in the bile in high concentrations. Ciprofloxacin is excreted in breast milk. Therefore, ciprofloxacin should be administered for the treatment of gonococcal uretritis or cervicitis only if ciprofloxacin-resistant Neisseria gonorrhoeae can be excluded. Elderly patients and women may be more sensitive to QTc-prolonging medications. Ciprofloxacin should be used in combination with other antimicrobial agents depending on the results of the microbiological documentation. Ciprofloxacin monotherapy is not suited for treatment of severe infections and infections that might be due to Gram-positive or anaerobic pathogens. Ciproxin® mÃ¥ ikke anvendes under graviditeten. The use of Ciprofloxacin should be avoided in patients who have experienced serious adverse reactions in the past when using quinolone or fluoroquinolone containing products (see section 4.8). İlaç Bilgileri (Güncelleme Tarihi:15.2.2018) Ciproxin 500 Mg 10 Tablet. (cannot be estimated from the available data), Bone marrow depression (life-threatening), Anaphylactic shock (life-threatening) (see section 4.4), Syndrome of inappropriate secretion of antidiuretic hormone (SIADH), (potentially culminating in suicidal ideations/thoughts or suicide attempts and completed suicide) (see section 4.4), Psychotic reactions (potentially culminating in suicidal ideations/ thoughts or suicide attempts and completed suicide), Seizures (including status epilepticus see section 4.4), Gait disturbance Olfactory nerve disorders, and torsades de pointes (reported predominantly in patients with risk factors for QT prolongation), ECG QT prolonged (see sections 4.4 and 4.9), Respiratory, Thoracic and Mediastinal Disorders, Antibiotic associated colitis (very rarely with possible fatal outcome) (see section 4.4), Liver necrosis (very rarely progressing to life-threatening hepatic failure) (see section 4.4), Photosensitivity reactions (see section 4.4), Stevens-Johnson syndrome (potentially life-threatening), Toxic epidermal necrolysis (potentially life-threatening), Acute Generalised Exanthematous Pustulosis (AGEP), Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), Musculo-skeletal and Connective Tissue Disorders*, Musculo-skeletal pain (e.g. Very rare cases of prolonged (continuing months or years), disabling and potentially irreversible serious adverse drug reactions affecting different, sometimes multiple, body systems (musculoskeletal, nervous, psychiatric and senses) have been reported in patients receiving quinolones and fluoroquinolones irrespective of their age and pre-existing risk factors. In such infections ciprofloxacin must be co-administered with other appropriate antibacterial agents. Ciprofloxacin tablets should not be taken with dairy products (e.g. Assunzione di ciproxin 500 mg per 6 giorni una al giorno e problemi ai tendini. Therefore, caution should be used prescribing ciprofloxacin concomitantly with sildenafil taking into consideration the risks and the benefits. It was demonstrated in healthy subjects that concomitant use of lidocaine containing medicinal products with ciprofloxacin, a moderate inhibitor of CYP450 1A2 isozyme, reduces clearance of intravenous lidocaine by 22%. Protein binding of ciprofloxacin is low (20-30%). Single doses of 100-750 mg produced dose-dependent maximum serum concentrations (Cmax) between 0.56 and 3.7 mg/L. Safety data from a randomised double-blind study on ciprofloxacin use in children (ciprofloxacin: n=335, mean age = 6.3 years; comparators: n=349, mean age = 6.2 years; age range = 1 to 17 years) revealed an incidence of suspected drug-related arthropathy (discerned from joint-related clinical signs and symptoms) by Day +42 of 7.2% and 4.6%. παραγράφους 4.4 και 5.1). Ciproxin 500 mg film-coated tablets are indicated for the treatment of the following infections (see sections 4.4 and 5.1). 10 mg/kg body weight twice daily to 20 mg/kg body weight twice daily with a maximum of 750 mg per dose. indlægsseddel. Patients with renal and hepatic impairment. They can be taken independent of mealtimes. Cases of hypoglycaemic coma have been reported. (See section 4.2 Elderly patients, section 4.5, section 4.8, section 4.9). - for heart valve regurgitation/incompetence (e.g. Streptococcal Infections (including Streptococcus pneumoniae). Therefore, concomitant use of corticosteroids should be avoided. (2): Methicillin-resistant S. aureus very commonly express co-resistance to fluoroquinolones. Due to its neurological effects, ciprofloxacin may affect reaction time. provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The restriction does not apply to antacids belonging to the class of H2 receptor blockers. Jernpræparater og syreneutraliserende midler, der indeholder aluminium og magnesium, nedsætter virkningen af Ciproxin®. Ciproxin® viene anche utilizzato a scopo profilattico nelle persone che hanno avuto contatti con meningite da neisseria meningitidis. SPECIES FOR WHICH ACQUIRED RESISTANCE MAY BE A PROBLEM, * Clinical efficacy has been demonstrated for susceptible isolates in approved clinical indications, + Resistance rate ≥ 50% in one or more EU countries, ($): Natural intermediate susceptibility in the absence of acquired mechanism of resistance. importanti informazioni per lei. Therefore, fluoroquinolones should only be used after careful benefit-risk assessment and after consideration of other therapeutic options in patients with positive family history of aneurysm disease or congenital heart valve disease, or in patients diagnosed with pre-existing aortic aneurysm and/or dissection or heart valve disease, or in presence of other risk factors or conditions predisposing: - for both aortic aneurysm and dissection and heart valve regurgitation/incompetence (e.g. Prima di iniziare la terapia, si deve prestare particolare … Special attention should be paid to available information on resistance to ciprofloxacin before commencing therapy. travellers' diarrhoea), • Infections of the skin and soft tissue caused by Gram-negative bacteria, • Prophylaxis of invasive infections due to Neisseria meningitidis, • Inhalation anthrax (post-exposure prophylaxis and curative treatment). Tendinitis and tendon rupture (especially but not limited to Achilles tendon), sometimes bilateral, may occur as early as within 48 hours of starting treatment with quinolones and fluoroquinolones and have been reported to occur even up to several months after discontinuation of treatment (see section 4.8). Yerli, Beşeri bir ilaçtır. Ciproxin 500 può essere prescritto anche per prevenire le infezioni provocate dal batterio Neisseria maningitidis o qualora il paziente sia entrato in contatto (inalandole) con spore di antrace. Continue, 2. Ciproxin® bør ikke anvendes til børn, da der er teoretisk risiko for beskadigelse af ledbrusken. The choice of ciprofloxacin should take into account information on resistance to ciprofloxacin in relevant pathogens in the countries visited. Based on population pharmacokinetic analysis of paediatric patients with various infections, the predicted mean half-life in children is approx. Treating physicians should refer to national and/or international consensus documents regarding the treatment of anthrax. Per l’elenco completo degli eccipienti, vedere paragrafo 6.1. Ciprofloxacin should be used with caution in patients with myasthenia gravis, because symptoms can be exacerbated (see section 4.8). If seizures occur ciprofloxacin should be discontinued (see section 4.8). During the combination, serum theophylline concentrations should be checked and the theophylline dose reduced as necessary (see section 4.4). Dopo quanto tempo fa effetto l’antibiotico ciproxin 500 per cistite Gli antibiotici sono usati per il trattamento o la prevenzione di infezioni batteriche. Ciprofloxacin may be used in the management of neutropenic patients with fever that is suspected to be due to a bacterial infection. Enkelte personer udvikler lyseksem, hvorfor det tilrÃ¥des at undgÃ¥ stærkt sollys og solarium. However, the concurrent administration of dairy products or mineral-fortified drinks alone (e.g. The rate of resistance to methicillin is around 20 to 50% among all staphylococcal species and is usually higher in nosocomial isolates. Ciproxin contiene il principio attivo ciprofloxacina. indlægsseddel). (1): Studies have been conducted in experimental animal infections due to inhalations of Bacillus anthracis spores; these studies reveal that antibiotics starting early after exposition avoid the occurrence of the disease if the treatment is made up to the decrease of the number of spores in the organism under the infective dose. 20 mg/kg body weight twice daily with a maximum of 750 mg per dose. Clinical trials have included children and adolescents aged 5-17 years. In the event of any signs and symptoms of hepatic disease (such as anorexia, jaundice, dark urine, pruritus, or tender abdomen), treatment should be discontinued. 02.0 Composizione qualitativa e quantitativa. The duration of treatment depends on the severity of the illness and on the clinical and bacteriological course. Plasmid-mediated resistance encoded by qnr-genes has been reported. They are for use only for species that have not been given a species-specific breakpoint and not for those species where susceptibility testing is not recommended. Single mutations may not result in clinical resistance, but multiple mutations generally result in clinical resistance to many or all active substances within the class. Ciprofloxacina con Cibi o Bevande. Neutropenic patients with fever that is suspected to be due to a bacterial infection. Ciprofloxacin reaches high concentrations in a variety of tissues such as lung (epithelial fluid, alveolar macrophages, biopsy tissue), sinuses, inflamed lesions (cantharides blister fluid), and the urogenital tract (urine, prostate, endometrium) where total concentrations exceeding those of plasma concentrations are reached. Psychiatric reactions may occur even after first administration of ciprofloxacin. Thus, the ability to drive or to operate machinery may be impaired. Severe infections and mixed infections with Gram-positive and anaerobic pathogens. Only a small quantity of ciprofloxacin (<10%) is eliminated by haemodialysis or peritoneal dialysis. - broncho-pulmonary infections in cystic fibrosis or in bronchiectasis, • Acute exacerbation of chronic sinusitis especially if these are caused by Gram-negative bacteria. “BAYER” on the reverse side.