Titolo Rivista Anno; High prevalence of autoimmune diseases in women with endometriosis. The 2016 study by Hay et al (17), one of the most recent studies evaluated, concluded that positivity of HPV DNA and consequently its “surrogate biomarker p16INK4a” in vulvar cancer marks a less aggressive form, while on the other hand p53 reactivity is related to a worse prognosis and a lower overall survival rate because of recurrence and disease-specific mortality. Maria Grazia Porpora 1 , Roberto Brunelli, Graziella Costa, Ludovica Imperiale, Ewa K Krasnowska, Thomas Lundeberg, Italo Nofroni, Maria Grazia Piccioni, … Adnexal masses are not common in pregnancy. Join Facebook to connect with Maria Grazia Piccioni and others you may know. They concluded that this location is more frequent in younger women (56.7 years vs. 63.1 for other vulvar sites), but the expression of these markers did not vary from one site to the other. Facebook gives people the power to share … Maria Grazia ha indicato 1 #esperienza lavorativa sul suo profilo. PubMed (MEDLINE), EMBASE, the Cochrane Library, Scopus as well as Clincaltrials.gov were systematically and independently screened by 2 authors (Carrone A, Savone D) and then compared to identify the eligible studies. However, its expression in vulvar carcinomas, which have a diverse pathogenesis, has not been extensively studied and only a few studies were reported in the scientific literature. 460 Followers, 366 Following, 55 Posts - See Instagram photos and videos from Maria Grazia Piccinini (@mariagrazia1) HPV DNA positivity also was distinguishable between uVIN and dVIN: the first type showed a significantly higher percentage (84%) of hrHPV positivity (also if adjacent SCC areas were present), while 100% of dVIN cases were hrHPV negative. This overlapping may lead to a certain level of subjectivity, as reported by some authors (19, 20). Differently from dVIN, there is no agreement on the gold-standard treatment for uVIN, which often presents multicentric and multifocal involvement. p16INK4a positivity levels were considered significant when there was intense and diffuse nuclear and cytoplasmic staining. View the profiles of people named Grazia Piccioni. : 335 60 94 596 Tel. the site you are agreeing to our use of cookies. Despite the bias of few comparable studies, our findings indicated that p16INK4a immunoreactivity could be a helpful tool to correctly classify VIN and VSCC according to their connection to hrHPV infection, and to overcome the problem that histological criteria often overlap. One-hundred and seventy-seven samples were considered: 123 cases of VIN, 41 cases of VSCC, and 13 benign squamous epithelium samples. 2 Department of Gynecological, Obstetrical and Urological Sciences, “Sapienza” University and Umberto I Polyclinic of Rome, Rome - Italy See all articles by this author. Ho preso visione della nota informativa. oppure compilare il modulo qui di seguito. Vi presentiamo la nostra nuova testimonial d'eccellenza. Normal vulvar epithelium, nondysplastic lesions and HPV-related uVIN and basaloid/warty VSCC were negative for p53, while nuclear and diffuse p53 immunostaining was detected in dVIN and keratinizing VSCC. Please check you selected the correct society from the list and entered the user name and password you use to log in to your society website. The characteristics and technical information of these 8 studies are listed in Table I. Maria Grazia Piccioni . Sono nata a Roma il 17 Dicembre del 1957 e nella mia città natale ho posto in essere i miei studi universitari. Also Reuschenbach et al (18) highlighted that hrHPV/p16 positivity is frequent in young women, irrespective of tumor site (anterior fourchette or other vulvar locations). HPV, VIN, p16INK4a immunochemistry and p53 were used as keywords. View or download all the content the society has access to. Facebook gives people the power to share … Angela Carrone, Lucia Riganelli, Delia Savone. Framarino dei Malatesta, Marialuisa and Piccioni, Maria Grazia and Gentile, Tiziana and Lauri, Michela and Benedetti Panici, Pierluigi (2007) Transabdominal intralesional injection of Methotrexate in two angular live ectopic pregnancies. Contatti; Categorie attivita. For HPV-related basaloid/warty VSCC, p16INK4 immunostaining was able to distinguish transforming HPV infections better than HPV DNA detection and with higher interobserver agreement. Finde heraus, was für Bäume piccioni maria grazia hat und was piccioni maria grazia tut, um die Welt ein bisschen grüner zu machen. Two independent reviewers evaluated all studies to verify the inclusion criteria and make sure the PRISMA guidelines were followed while elaborating this review. However, combined modalities with topical treatment (imiquimod or cidofovir) and a surgical approach may represent the best treatment for this multiform disease (13, 19, 20, 22–23–24). Join Facebook to connect with Grazia Piccioni and others you may know. Visualizza i profili delle persone di nome Grazia Piccioni. HPV16 was the predominant genotype, followed by HPV18 and HPV33. Immunohistochemistry was performed in 3,110 specimens with a histological diagnosis of VIN and VSCC, including also 2% (n = 63) of samples of normal epithelium or nondysplastic lesions (hyperplasia, lichen sclerosus, lichen simplex chronicus, seborrheic keratosis, condylomas). Chiudendo questo banner, scorrendo questa pagina o cliccando qualunque suo elemento acconsenti all’uso dei cookie. L., Marzetti; G. M., Galati; Pecorini, Francesco; Piccioni, Maria Grazia 11 Comparison of three-dimensional ultrasonography and diagnostic hysteroscopy in differential diagnosis of uterine malformations and uterine myomas Simply select your manager software from the list below and click on download. The incidence of HPV-related VIN is increasing worldwide and is implicated in carcinogenesis. Discrepancies were not infrequent in this study. Sharing links are not available for this article. A risk of bias across the assessed studies was due to the not perfectly homogeneous interpretation of p16INK4a expression and the different kits used for immunostaining; thus, it will be necessary to standardize the nuclear and cytoplasmic scoring system and the immunohistochemistry technique. Nel dramma la Ginzburg disegna il ritratto di un matrimonio, di carattere piuttosto borghese, tra l'avvocato Pietro e Giuliana, una giovane donna di bassa estrazione sociale conosciuta ad una festa. Search Google Scholar for this author, Pierluigi Benedetti Panici. Svolge il suo lavoro con piena dedizione e passione, e' interessata ad una paziente e veramente vuole aiutarle. E' stata molto gentile ed umana e posso dire di essere stata visitata da una persona esperta e competenta. Facebook gives people the power to share and makes the world more open and connected. Non hai trovato sul profilo dello specialista le informazioni che cercavi? Intervista alla Dott.ssa Maria Grazia Piccioni per il programma Live Social. In specimens of keratinizing VSCC, HPV positivity ranged from 1.3 to 13.3% and p53 immunostaining was positive in 64.5% of cases where evaluated. In 2004, the International Society for the Study of Vulvar Disease (ISSVD) proposed this VIN classification: HPV-associated usual VIN (uVIN, classic or bowenoid) and HPV-unrelated or differentiated VIN (dVIN, or simplex) (6). Home » Intervista alla Dott.ssa Maria Grazia Piccioni – Parto Naturale, Cesareo, Indotto Maria Grazia Cucinotta (born 27 July 1968) is an Italian actress who has featured in many films and television series since 1990. Maria Di Grazia. Contact us if you experience any difficulty logging in. Review studies indicated that p16INK4a or p16INK4a/p53 immunoreactivity along with histological diagnostics could adequately classify VIN and its connection to HPV infection. Risulta sempre disponibile e, in caso di necessità, rintracciabile. These findings could be useful to personalize surgical and adjuvant treatments basing on different molecular profiles, but in the patient series studied by Alonso et al (8) HPV/p16-positive VSCC showed a similar prognosis to HPV/p16-negative VSCC. All included studies allowed comparison of immunochemistry triage with HPV DNA PCR test. The aim of this review is therefore to collect studies that evaluated p16INK4a immunostaining in vulvar histological disorders, in order to define the prognosis and management of both uVIN and dVIN. … Official FaceBook Fan Page I prezzi indicati sono quelli per pazienti senza assicurazione sanitaria, Informazioni su servizi e prezzi non disponibili. We included all English-language retrospective and prospective studies at primary diagnosis assessing p16INK4a immunostaining or p16INK4a/p53 staining, with HPV DNA testing (HC2/PCR) as the comparator test, on histological specimens of VIN and VSCC verified with a reference standard. Some society journals require you to create a personal profile, then activate your society account, You are adding the following journals to your email alerts, Did you struggle to get access to this article? Conflict of interest: The authors declare they have no competing interests related to this article. Devo ringraziare le persone che me l'hanno consigliata perchè mi hanno permesso di conoscere una persona splendida sotto ogni punto di vista, sia umano che professionale. Maria Grazia Piccioni. Directions: Search the directions to Sinatra Dr. maria Grazia, Milano, Italia Google Maps Address: Search on Google Maps with the address Sinatra Dr. maria Grazia, Milano, Italia Google Maps GPS: Search on Google Maps with the GPS Sinatra Dr. maria Grazia, Milano, Italia Hotels: Search a Hotel in Milano, Italia Hostels: Search a Hostel in Milano, Italia l meglio: Ho apprezzato molto il fatto che facesse molte domande, proprio per essere sicura di aver preso in considerazione tutte le ipotesi. Contatti. Vulvar squamous cell carcinoma is a multifactorial disease following two separate and independent pathways, p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia, p16 overexpression identifies HPV-positive vulvar squamous cell carcinomas, Management of HPV-related cervical disease: role of p16INK4a immunochemistry, A panel of p16(INK4A), MIB1 and p53 proteins can distinguish between the 2 pathways leading to vulvar squamous cell carcinoma, p16INK4A expression as biomarker for HPV 16-related vulvar neoplasias, Human papillomavirus infection and p16(INK4a) protein expression in vulvar intraepithelial neoplasia and invasive squamous cell carcinoma, Biomarkers p16, human papillomavirus and p53 predict recurrence and survival in early stage squamous cell carcinoma of the vulva, Medical and surgical interventions for the treatment of usual-type vulval intraepithelial neoplasia, Imiquimod 5% cream versus cold knife excision for treatment of VIN 2/3: a five-year follow-up, Vulvar intraepithelial neoplasia with superficially invasive carcinoma of the vulva, Surgical management and prognostic factors of vulvovaginal melanoma, Prognostic role of inguinal lymphadenectomy in vulvar squamous carcinoma: younger and older patients should be equally treated, Modified gluteal fold advancement V-Y flap for vulvar reconstruction after surgery for vulvar malignancies, Prognostic importance of human papillomavirus (HPV) and p16 positivity in squamous cell carcinoma of the vulva treated with radiotherapy, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, HPV-related Vulvar Diseases and Perspectives of p16, http://www.iarc.fr/en/publications/pdfs-online/epi/sp160/CI5vol9.pdf, http://www.cancerresearchuk.org/about-cancer/type/vulval-cancer/about/risks-and-causes-of-vulval-cancer, http://seer.cancer.gov/statfacts/html/vulva.html.